チームリーダー
王 丹*
Ph.D.
脳エピトランスクリプトミクス研究チーム
[2024年3月 終了]
*現連絡先 ohtan.wang[at]nyu.edu
[at]を@に変えてください
RNAの時空間的な制御機構「エピトランスクリプトミクス」の中枢神経系における役割解明を目指します。特に学習・記憶、認知機能に焦点を当て、オミックス解析、蛍光イメージング、細胞生物学的手法、マウスモデル系によりアプローチします。
研究テーマ
- シナプス機能におけるRNA修飾の役割の解明
- 分子から行動までの各層におけるRNA修飾読み取り分子の役割の解明
- 各ライフステージにおけるRNA修飾状況の探索
主要論文
Madugalle SU, Meyer K, Wang DO, Bredy TW.
RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain.
Trends in Neurosciences
43, 1011-1023 Tue Dec 01 00:00:00 JST 2020
doi: 10.1016/j.tins.2020.09.005
Roy R, Shiina N, Wang DO.
More dynamic, more quantitative, unexpectedly intricate: advanced understanding on synaptic RNA localization in learning and memory.
Neurobiology of Learning and Memory
168, 107149 Thu Oct 01 00:00:00 JST 2020
doi: 10.1016/j.nlm.2019.107149
Kashida S, Wang DO, Saito H, Gueroui Z.
Nanoparticle-based local translation reveals mRNA as translation-coupled scaffold with anchoring function.
Proceedings of the National Academy of Sciences of the United States of America
116(27), 13346-13351 Sun Dec 01 00:00:00 JST 2019
doi: 10.1073/pnas.1900310116
Wang DO.
Mapping m6A and m1A with mutation signatures.
Nature methods
16(12), 1213-1214 Sun Dec 01 00:00:00 JST 2019
doi: 10.1038/s41592-019-0636-z
Merkurjev D, Hong WT, Iida K, et al.
Synaptic N6 methyladenosine (m6A) reveals functional partitioning of localized transcripts.
Nature Neuroscience
21, 1004-1014 Sat Dec 01 00:00:00 JST 2018
doi: 10.1038/s41593-018-0173-6
Oomoto I, Suzuki-Hirano A, Umeshima H, et al.
ECHO-liveFISH: in vivo RNA labeling reveals dynamic regulation of nuclear RNA foci in living tissues.
Nucleic acids research
43(19), e126 Fri Oct 30 00:00:00 JST 2015
doi: 10.1093/nar/gkv614
Meer EJ, Wang DO, Kim S, et al.
Identification of a cis-acting element that localizes mRNA to synapses.
Proceedings of the National Academy of Sciences of the United States of America
109(12), 4639-4644 Tue Mar 20 00:00:00 JST 2012
doi: 10.1073/pnas.1116269109
Wang DO, Martin KC, Zukin RS.
Spatially restricting gene expression by local translation at synapses.
Trends in Neurosciences
33(4), 173-82 Wed Dec 01 00:00:00 JST 2010
doi: 10.1016/j.tins.2010.01.005
Wang DO, Kim SM, Zhao Y, et al.
Synapse- and stimulus-specific local translation during long-term neuronal plasticity.
Science
324(5934), 1536-40 Tue Dec 01 00:00:00 JST 2009
doi: 10.1126/science.1173205
