チームリーダー
白水美香子 Ph.D.

タンパク質機能・構造研究チーム

拠点横浜

E-mail mikako.shirouzu[at]riken.jp

[at]を@に変えてください

採用情報

研究員または特別研究員募集（BDR-23-103）

研究員または特別研究員募集（PFSB2201）

創薬・医療等のライフイノベーションに貢献する構造解析技術基盤を構築

個別化医療を実現する薬の開発においては、ターゲットとなる疾患に関与するタンパク質の機能と構造の情報の蓄積が一層重要となります。これまで解析が難しかった膜タンパク質をはじめとする高難度タンパク質の試料調製法や、生体分子複合体のクライオ電子顕微鏡による解析技術の開発を進めながら、創薬・医療等のライフイノベーションに貢献する構造解析技術の基盤を構築します。立体構造情報は、候補化合物のインシリコスクリーニングや動的構造計算に供され、創薬への貢献や、細胞機能のシミュレーション研究へと発展することが期待されます。

主要論文

Akiyama N, Ishiguro K, Yokoyama T, et al.
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine.
Nature Structural & Molecular Biology Wed Mar 27 00:00:00 JST 2024 doi: 10.1038/s41594-024-01238-1

Suzuki M, Uchibori K, Oh-Hara T, et al.
A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer.
Npj Precision Oncology 8(1), 46 Fri Feb 23 00:00:00 JST 2024 doi: 10.1038/s41698-024-00542-9

Tanaka M, Yokoyama T, Saito H, et al.
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
Nature Chemical Biology Wed Jan 24 00:00:00 JST 2024 doi: 10.1038/s41589-023-01513-0

Furutani Y, Hirano Y, Toguchi M, et al.
A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor.
Cell Death Discovery 9(1), 467 Fri Dec 22 00:00:00 JST 2023 doi: 10.1038/s41420-023-01755-w

Zhao X, Ma D, Ishiguro K, et al.
Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell 186(25), 5517-5535.e24 Thu Dec 07 00:00:00 JST 2023 doi: 10.1016/j.cell.2023.10.026

Kikuchi M, Morita S, Wakamori M, et al.
Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
Nature Communications 14(1), 4103 Mon Jul 17 00:00:00 JST 2023 doi: 10.1038/s41467-023-39735-4

Yamagata A, Murata Y, Namba K, et al.
Uptake mechanism of iron-phytosiderophore from the soil based on the structure of yellow stripe transporter.
Nature Communications 13, 7180 Wed Nov 23 00:00:00 JST 2022 doi: 10.1038/s41467-022-34930-1

Ehara H, Kujirai T, Shirouzu M, et al.
Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Science 377(6611), eabp9466 Fri Sep 09 00:00:00 JST 2022 doi: 10.1126/science.abp9466

Nakamura H, Hisano T, Rahman MM, et al.
Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria.
Proceedings of the National Academy of Sciences of the United States of America 119(27), e2123385119 Tue Jul 05 00:00:00 JST 2022 doi: 10.1073/pnas.2123385119

Park JH, Iwamoto M, Yun JH, et al.
Structural insights into the HBV receptor and bile acid transporter NTCP.
Nature 606(7916), 1027-1031 Wed Jun 01 00:00:00 JST 2022 doi: 10.1038/s41586-022-04857-0

Hosaka T, Nomura T, Kubo M, et al.
Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers.
Proceedings of the National Academy of Sciences of the United States of America 119(9), e2117433119 Tue Mar 01 00:00:00 JST 2022 doi: 10.1073/pnas.2117433119

Nakagawa Y, Shen HC, Komi Y, et al.
Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system.
Nature Chemical Biology 18(3), 321-331 Tue Mar 01 00:00:00 JST 2022 doi: 10.1038/s41589-021-00951-y

Kasahara K, Re S, Nawrocki G, et al.
Reduced Efficacy of a Src Kinase Inhibitor in Crowded Protein Solution.
Nature Communications 12, 4099 Wed Dec 01 00:00:00 JST 2021 doi: 10.1038/s41467-021-24349-5

Kukimoto-Niino M, Katsura K, Kaushik R, et al.
Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex.
Science Advances 7(30), eabg3147 Thu Jul 01 00:00:00 JST 2021 doi: 10.1126/sciadv.abg3147