BDR Center Project
RIKEN BDR has launched six cross-center projects. We will continue to promote collaborative research across disciplines, taking advantage of the strength of our researchers who work in diverse research fields.
This project aims to develop DECODE technology: to estimate, predict and manipulate the cell states by observing and analyzing images of changing cells using state-of-the-art measurement technology and artificial intelligence.
The project aims to establish a research phase pipeline to realize applications using organoid technologies. We will promote next-generation organoid research at all phases of the pipeline in parallel, from the elucidation of the principles of self-organization to the optimization and standardization of organoids for societal implementation.
Torpor—an active hypometabolic state in mammals—may impact the physiological condition of the animal in any stage of the life cycle, including development, growth and aging, however, the underlying mechanism of torpor is poorly understood. The QMIN project will drive torpor research by revealing, manipulating, and recapitulating torpor phenomena in vivo and in vitro and aim to translate our knowledge of torpor to applications to benefit human society.
Structural Cell Biology Project
In the cell, biological macromolecules such as proteins, DNA, and RNA form various complexes and multilayered structures that are essential for supporting cellular functions. However, their structures, interactions, and action mechanisms remain largely unknown. This project aims to develop technologies to approach these entities and to bridge the gap in knowledge between molecules and cells to further our understanding of life.
Research Automation Project
This project aims to leverage state-of-the-art robotics and information technology in biological research processes. We will develop various automation technology ranging from experimental robotics, data-processing workflow, and any other topics relevant to scientific projects within BDR such as automated experimental designs and hypothesis generation with the ultimate aim to accelerate the entire research and development cycles at BDR.
Stage Transition Project
From embryonic development to postnatal maturation, between the states of homeostasis, disease, and aging, an organism undergoes major, non-linear stage transitions during its life cycle. This project aims to elucidate the mechanisms underlying known stage transitions, identify new transitional phenomena, and develop novel theories and technologies to analyze the transitions. These endeavors will pave the way for manipulations of stage transitions to safeguard human development in the future.