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Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

Outreach

Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

News

News

From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder

Team Leader (Apr. 2018 - Aug. 2022)
Yo Tanaka* Ph.D. (Eng.)
Team Leader (Sep. 2022 - )
Eisuke Nishida Ph.D.

Laboratory for Integrated Biodevice

[Closed Mar. 2023]

*Current email address : yo.tanaka[at]a.riken.jp

Please replace [at] with @.

Innovating biology by microdevices

This laboratory aims to promote integration and sophistication of biological experiments using micro structures and channels based on semiconductor fabrication methods. These sizes are near the size of hair or mosquito needle width (10~100 μm) or less. By exploiting these devices to chemical or biological fields, precise cell or molecular handling can be realized. Furthermore, our group focuses on unique functions of cells or tissue of living creatures. By combining this with microfabrication technology, we aim to new functional devices and propose future ideal machine models.

Research Theme

  • Integrated and sophisticated biological experiments
  • Novel micro- and nano-size biological devices

Selected Publications

Tanaka Y, Amaya S, Funano SI, et al.
A pressure driven electric energy generator exploiting a micro- to nano-scale glass porous filter with ion flow originating from water.
Scientific Reports 12(1), 16827 Thu Oct 20 00:00:00 JST 2022 doi: 10.1038/s41598-022-21069-8

Tanaka Y, Ma D, Amaya S, et al.
Anhydrobiotic chironomid larval motion-based multi-sensing microdevice for the exploration of survivable locations.
iScience 25(8), 104639 Fri Aug 19 00:00:00 JST 2022 doi: 10.1016/j.isci.2022.104639

Aishan Y, Funano SI, Sato A, et al.
Bio-actuated microvalve in microfluidics using sensing and actuating function of Mimosa pudica.
Scientific Reports 12(1), 7653 Mon May 23 00:00:00 JST 2022 doi: 10.1038/s41598-022-11637-3

Aishan Y, Yalikun Y, Shen Y, et al.
A chemical micropump actuated by self-oscillating polymer gel.
Sensors and Actuators B: Chemical 337, 129769 Wed Dec 01 00:00:00 JST 2021 doi: 10.1016/j.snb.2021.129769

Yuan Y, Yalikun Y, Amaya S, et al.
Fabrication of ultra-thin glass sheet by weight-controlled load-assisted precise thermal stretching.
Sensors and Actuators A: Physical 321, 112604 Mon Nov 01 00:00:00 JST 2021 doi: 10.1016/j.sna.2021.112604

Funano SI, Ota N, Tanaka Y.
A simple and reversible glass-glass bonding method to construct a microfluidic device and its application for cell recovery.
Lab on a chip Tue Apr 27 00:00:00 JST 2021 doi: 10.1039/d1lc00058f

Yamamoto K, Ota N, Tanaka Y.
Nanofluidic Devices and Applications for Biological Analyses.
Analytical chemistry 93(1), 332-349 Tue Jan 12 00:00:00 JST 2021 doi: 10.1021/acs.analchem.0c03868

Funano S, Tanaka N, Amaya S, et al.
Movement tracing and analysis of benthic sting ray (Dasyatis akajei) and electric ray (Narke japonica) toward seabed exploration.
SN Applied Sciences 2, 2142 Tue Dec 01 00:00:00 JST 2020 doi: 10.1007/s42452-020-03967-6

Abulaiti M, Yalikun Y, Murata K, et al.
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function.
Scientific Reports 10, 19201 Sun Nov 01 00:00:00 JST 2020 doi: 10.1038/s41598-020-76062-w

Shen Y, Yalikun Y, Aishan Y, et al.
Area cooling enables thermal positioning and manipulation of single cells.
Lab on a chip 20(20), 3733-3743 Wed Oct 21 00:00:00 JST 2020 doi: 10.1039/d0lc00523a

Funano SI, Tone D, Ukai H, et al.
Rapid and easy-to-use ES cell manipulation device with a small groove near culturing wells.
BMC research notes 13(1), 453 Mon Oct 05 00:00:00 JST 2020 doi: 10.1186/s13104-020-05294-w

Shen Y, Tanaka N, Yamazoe H, et al.
Flow analysis on microcasting with degassed polydimethylsiloxane micro-channels for cell patterning with cross-linked albumin.
PLoS ONE 15(5), e0232518 Wed Jul 01 00:00:00 JST 2020 doi: 10.1371/journal.pone.0232518

Katayama R, Tanaka N, Takagi Y, et al.
Characterization of the Hydration Process of Phospholipid-Mimetic Polymers Using Air-Injection-Mediated Liquid Exclusion Methods.
Langmuir : the ACS journal of surfaces and colloids 36(20), 5626-5632 Tue May 26 00:00:00 JST 2020 doi: 10.1021/acs.langmuir.0c00953

Aishan Y, Yalikun Y, Amaya S, et al.
Thin glass micro-dome structure based microlens fabricated by accurate thermal expansion of microcavities.
Applied Physics Letters 115, 263501 Sun Dec 01 00:00:00 JST 2019 doi: 10.1063/1.5123186

Ota N, Kanda GN, Moriguchi H, et al.
A Microfluidic Platform Based on Robust Gas and Liquid Exchange for Long-Term Culturing of Explanted Tissues.
Analytical Sciences 35(10), 1141-1147 Fri Nov 01 00:00:00 JST 2019 doi: 10.2116/analsci.19P099

Kawai T, Ota N, Okada K, et al.
Ultrasensitive single cell metabolomics by capillary electrophoresis–mass spectrometry with a thin-walled tapered emitter and large-volume dual sample preconcentration.
Analytical Chemistry 91, 10564-10572 Tue Oct 01 00:00:00 JST 2019 doi: 10.1021/acs.analchem.9b01578

Ota N, Yonamine Y, Asai T, et al.
Isolating Single Euglena gracilis Cells by Glass Microfluidics for Raman Analysis of Paramylon Biogenesis.
Analytical chemistry 91(15), 9631-9639 Sun Sep 01 00:00:00 JST 2019 doi: 10.1021/acs.analchem.9b01007

Tanaka Y, Funano SI, Noguchi Y, et al.
A valve powered by earthworm muscle with both electrical and 100% chemical control.
Scientific reports 9(1), 8042 Thu Aug 01 00:00:00 JST 2019 doi: 10.1038/s41598-019-44116-3

Tanaka N, Kogo T, Hirai N, et al.
In-situ detection based on the biofilm hydrophilicity for environmental biofilm formation.
Scientific reports 9(1), 8070 Mon Jul 01 00:00:00 JST 2019 doi: 10.1038/s41598-019-44167-6

Tanaka N, Yamashita T, Yalikun Y, et al.
An ultra-small fluid oscillation unit for pumping driven by self-organized three-dimensional bridging of pulsatile cardiomyocytes on elastic micro-piers.
Sensors and Actuators B: Chemical 293, 256-264 Sat Jun 01 00:00:00 JST 2019 doi: 10.1016/j.snb.2019.04.087

Shen Y, Yalikun Y, Tanaka Y.
Recent advances in microfluidic cell sorting systems.
Sensors and Actuators B: Chemical 282, 268-281 Wed May 01 00:00:00 JST 2019 doi: 10.1016/j.snb.2018.11.025

Ota N, Yalikun Y, Tanaka N, et al.
Simple Isolation of Single Cell: Thin Glass Microfluidic Device for Observation of Isolated Single Euglena gracilis Cells.
Analytical sciences 35(5), 577-583 Mon Apr 01 00:00:00 JST 2019 doi: 10.2116/analsci.18P568

Ota N, Yalikun Y, Suzuki T, et al.
Enhancement in acoustic focusing of micro and nanoparticles by thinning a microfluidic device.
Royal Society Open Science 6, 181776 Fri Mar 01 00:00:00 JST 2019 doi: 10.1098/rsos.181776

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