Team Leader
Koichi Takahashi
Ph.D.
Laboratory for Biologically Inspired Computing
LocationKobe / Integrated Innovation Bldg
and Osaka / Quantitative Biology Buildings
E-mailktakahashi[at]riken.jp
Please replace [at] with @.
We are pursuing two different but mutually interconnected research interests: research and development of biologically inspired computing architectures including artificial neural networks and applying such advanced information processing technologies to life science research. More specifically, we are working on development of BriCA (Brain-inspired Computing Architecture), a high-performance software platform for brain-inspired computing, development of high-performance genome-scale simulation software platform E-Cell System, and automating various processes in biological experiments by combining robotics and AI.
Research Theme
- Genome-scale cell simulation software platform
- Robotic biology
- Brain-inspired computing architectures
Selected Publications
Kanda GN, Tsuzuki T, Terada M, et al.
Robotic search for optimal cell culture in regenerative medicine.
eLife
11, e77007 Tue Jun 28 00:00:00 JST 2022
doi: 10.7554/eLife.77007
Ochiai K, Motozawa N, Terada M, et al.
A Variable Scheduling Maintenance Culture Platform for Mammalian Cells.
SLAS technology
26(2), 209-217 Thu Apr 01 00:00:00 JST 2021
doi: 10.1177/2472630320972109
Watabe M, Yoshimura H, Arjunan SNV, et al.
Signaling activations through G-protein-coupled-receptor aggregations.
Phys Rev E.
102, 032413 Tue Sep 22 00:00:00 JST 2020
doi: 10.1103/PhysRevE.102.032413
Yachie N, Natsume T, Takahashi K, et al.
Robotic crowd biology with Maholo LabDroids.
Nature Biotechnology
35(4), 310-312 Fri Dec 01 00:00:00 JST 2017
doi: 10.1038/nbt.3758
Yamakawa H, Arakawa N, Takahashi K, et al.
Reinterpreting The Cortical Circuit
Pre-proceedings of the IJCAI-17 Workshop on Architectures for Generality & Autonomy
Sat Aug 19 00:00:00 JST 2017
Iwamoto K, Shindo Y, Takahashi K.
Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway.
Plos Computational Biology
12(11), e1005222 Thu Dec 01 00:00:00 JST 2016
doi: 10.1371/journal.pcbi.1005222
Itaya K, Takahashi K, Nakamura M, et al.
BriCA: A modular software platform for whole brain architecture
Neural information processing – 23rd international conference, ICONIP
Sun Oct 16 00:00:00 JST 2016
Shindo Y, Iwamoto K, Mouri K, et al.
Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling.
Nature Communications
7, 10485 Sat Oct 01 00:00:00 JST 2016
doi: 10.1038/ncomms10485
Karr JR, Takahashi K, Funahashi A.
The principles of whole-cell modeling.
Current Opinion in Microbiology
27, 18-24 Tue Dec 01 00:00:00 JST 2015
doi: 10.1016/j.mib.2015.06.004
Watabe M, Arjunan SNV, Fukushima S, et al.
A Computational Framework for Bioimaging Simulation.
Plos One
10(7), e0130089 Sun Nov 01 00:00:00 JST 2015
doi: 10.1371/journal.pone.0130089
Shimo H, Arjunan SNV, Machiyama H, et al.
Particle Simulation of Oxidation Induced Band 3 Clustering in Human Erythrocytes.
Plos Computational Biology
11(6), UNSP e1004 Thu Oct 01 00:00:00 JST 2015
doi: 10.1371/journal.pcbi.1004210
Kaizu K, de Ronde W, Paijmans J, et al.
The Berg-Purcell Limit Revisited.
Biophysical Journal
106(4), 976-985 Mon Dec 01 00:00:00 JST 2014
doi: 10.1016/j.bpj.2013.12.030
Hihara S, Pack CG, Kaizu K, et al.
Local Nucleosome Dynamics Facilitate Chromatin Accessibility in Living Mammalian Cells.
Cell Reports
2(6), 1645-1656 Sat Dec 01 00:00:00 JST 2012
doi: 10.1016/j.celrep.2012.11.008
