Team Leader
Fumiaki Obata Ph.D.

Laboratory for Nutritional Biology

LocationKobe / Developmental Biology Buildings

E-mailfumiaki.obata[at]riken.jp

Please replace [at] with @.

What’s New

Mar. 26, 2024 Research

Flies fed restricted diet in early adulthood live longer

Mar. 15, 2024 BDR News

Dive into BDR's intriguing research

The Desire to Explain Nutrition Properly

Unveiling the "logic" behind the dietary regulation of healthspan

The organismal healthspan is significantly influenced by the quality and quantity of the diet, but our understanding of the detailed molecular mechanisms remains limited. In our laboratory, we study the physiological functions of various nutrients during each life stage, including development, growth, reproduction, and aging. We aim to elucidate the adaptive mechanisms in response to nutritional imbalances, whether transient or chronic, and their impact on molecular mechanisms related to metabolic physiology, tissue homeostasis, feeding behavior, stress response, reproductive capacity, and overall lifespan.

Research Themes

Lifespan Extension through Dietary Restriction
Specific Sensing of Nutrients and the Adaptive Mechanism to their Deficiency
Healthspan Changes by Early-life Dietary Environment
Blood-feeding Behavior and Metabolic Homeostasis in Mosquitoes

Research Themes in Detail

Selected Publications

Kosakamoto H, Miura M, Obata F.
Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila.
Development 151(1), dev202372 Mon Jan 01 00:00:00 JST 2024 doi: 10.1242/dev.202372

Kosakamoto H, Obata F, Kuraishi J, et al.
Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila.
Nature Communications 14(1), 7832 Tue Dec 05 00:00:00 JST 2023 doi: 10.1038/s41467-023-43550-2

Onuma T, Yamauchi T, Kosakamoto H, et al.
Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan.
PLOS Genetics 19(4), e1010709 Sat Apr 01 00:00:00 JST 2023 doi: 10.1371/journal.pgen.1010709

Kosakamoto H, Okamoto N, Aikawa H, et al.
Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila.
Nature Metabolism 4(7), 944-959 Fri Jul 01 00:00:00 JST 2022 doi: 10.1038/s42255-022-00608-7

Yamauchi T, Oi A, Kosakamoto H, et al.
Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila.
iScience 23, 101477 Wed Sep 02 00:00:00 JST 2020 doi: 10.1016/j.isci.2020.101477

Kosakamoto H, Yamauchi T, Akuzawa-Tokita Y, et al.
Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila.
Cell Reports 32(3), 107938 Tue Jul 21 00:00:00 JST 2020 doi: 10.1016/j.celrep.2020.107938

Obata F, Tsuda-Sakurai K, Yamazaki T, et al.
Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine.
Developmental Cell 44(6), 741-751 Mon Mar 26 00:00:00 JST 2018 doi: 10.1016/j.devcel.2018.02.017

Obata F, Fons CO, Gould AP.
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
Nature Communications 9(1), 975 Wed Mar 07 00:00:00 JST 2018 doi: 10.1038/s41467-018-03070-w

All Publications