Team Leader
Hidefumi Mukai
Ph.D.
Laboratory for Molecular Delivery and Imaging Technology
[Closed Mar. 2023]
E-mailhmukai[at]riken.jp
Please replace [at] with @.
The objective of our team is to develop evaluation and verification technologies of the function of control molecules in situ and in vivo, and to develop an efficient Drug Delivery System (DDS).
Research Theme
- Development of bacterial machines for cancer therapy
- Biomacromolecular PET probes: ADME studies and imaging biomarker development
- Application of inorganic- and bio-nanoparticles to DDS
Selected Publications
Mukai H, Watanabe Y.
Review: PET imaging with macro- and middle-sized molecular probes.
Nuclear medicine and biology
92, 156-170 Fri Jan 01 00:00:00 JST 2021
doi: 10.1016/j.nucmedbio.2020.06.007
Nomura S, Takahashi M, Hashiba Kato A, et al.
Biosorption-based 64Cu-labeling of bacteria for pharmacokinetic positron-emission tomography.
International Journal of Pharmaceutics
590, 119950 Tue Dec 01 00:00:00 JST 2020
doi: 10.1016/j.ijpharm.2020.119950
Sakai K, Passioura T, Sato H, et al.
Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.
Nature Chemical Biology
15, 598-606 Sun Dec 01 00:00:00 JST 2019
doi: 10.1038/s41589-019-0285-7
Ren Q, Mohri K, Warashina S, et al.
Improved immuno-PET imaging of HER2-positive tumors in mice: Urokinase injection-triggered clearance enhancement of 64Cu-trastuzumab.
Molecular Pharmaceutics
16(3), 1065-1073 Fri Nov 01 00:00:00 JST 2019
doi: 10.1021/acs.molpharmaceut.8b01052
Mukai H, Hatanaka K, Yagi N, et al.
Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis.
Journal of Controlled Release
294, 185-194 Tue Oct 01 00:00:00 JST 2019
doi: 10.1016/j.jconrel.2018.12.006
Nakamoto Y, Pradipta AR, Mukai H, et al.
Expanding the applicability of the metal labeling of biomolecules by the RIKEN click reaction: A case study with Gallium‐68 positron emission tomography.
Chembiochem
19, 2055-2060 Sat Dec 01 00:00:00 JST 2018
doi: 10.1002/cbic.201800335
Matsumura K, Zouda M, Wada Y, et al.
Urokinase injection-triggered clearance enhancement of a 4-arm PEG-conjugated 64Cu-bombesin analog tetramer: A novel approach for the improvement of PET imaging contrast.
International Journal of Pharmaceutics
545, 206-214 Thu Nov 01 00:00:00 JST 2018
doi: 10.1016/j.ijpharm.2018.05.014
Mukai H, Takahashi M, Watanabe Y.
Potential usefulness of Brevibacillus for bacterial cancer therapy: intratumoral provision of tumor necrosis factor- α and anticancer effects.
Cancer Gene Therapy
25, 47-57 Mon Oct 01 00:00:00 JST 2018
doi: 10.1038/s41417-017-0009-7
Otani Y, Kawakami S, Mukai H, et al.
Long-term in vivo gene expression in mouse kidney using φ31 integrase and electroporation.
Journal of Drug Targeting
23, 427-435 Tue Dec 01 00:00:00 JST 2015
doi: 10.3109/1061186X.2014.1002788
Mukai H, Ozaki D, Cui YL, et al.
Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with 18 F-incorporated oligodeoxynucleotides.
Journal of Controlled Release
180, 92-99 Mon Dec 01 00:00:00 JST 2014
doi: 10.1016/j.jconrel.2014.02.014
Mukai H, Wada Y, Watanabe Y.
The synthesis of 64 Cu-chelated porphyrin photosensitizers and their tumor-targeting peptide conjugates for the evaluation of target cell uptake and PET image-based pharmacokinetics of targeted photodynamic therapy agents.
Annals of Nuclear Medicine
27, 625-639 Sun Dec 01 00:00:00 JST 2013
doi: 10.1007/s12149-013-0728-2
Mukai H, Kawakami S, Takahashi H, et al.
Key physiological phenomena governing transgene expression based on tissue pressure-mediated transfection in mice.
Biological and Pharmaceutical Bulletin
33, 1627-1632 Wed Dec 01 00:00:00 JST 2010
doi: 10.1248/bpb.33.1627
Mukai H, Kawakami S, Kamiya Y, et al.
Pressure-mediated transfection of murine spleen and liver.
Human Gene Therapy
20, 1157-1167 Tue Dec 01 00:00:00 JST 2009
doi: 10.1089/hum.2008.213
Ohyama J, Hitomi Y, Higuchi Y, et al.
One-Phase Synthesis of Small Gold Nanoparticles Coated by a Horizontal Porphyrin Monolayer.
Chemical Communications
47, 6300-6302 Mon Dec 01 00:00:00 JST 2008
doi: 10.1039/b815100h
Members
Team LeaderHidefumi Mukai
- hmukai[at]riken.jp
(Please replace [at] with @)
Research ScientistKohta Mohri
- kota.mori[at]riken.jp
Research ScientistShota Warashina
Postdoctoral ResearcherShoko Nomura
Research AssociateMaiko Takahashi
- mtakahashi[at]riken.jp
Temporary StaffingNaomi Fujie
Assistant*Yoko Nagatomo
(*:concurrent / Please replace [at] with @.)