logomark
Research

Research

BDR researchers coming from diverse research fields are working together to achieve higher goals.

Seminars & Symposia

Seminars & Symposia

BDR hosts annual symposium and regular seminars inviting international scientists in life science.

Careers & Study

Careers & Study

BDR embraces people from diverse backgrounds, and strives to create an open and supportive setting for research.

Outreach

Outreach

BDR communicates the appeal and significance of our research to society through the use of various media and activities.

News

News

From research, events, people and everything in between, find out what’s going on at RIKEN BDR.

About Us

About Us

Exploring the scientific foundations of life through interdisciplinary approaches to address society’s problems.

Photo of Team leder, Yoshihiro Morishita

Team Leader
Yoshihiro Morishita Ph.D.

Laboratory for Developmental Morphogeometry

LocationKobe

E-mailyoshihiro.morishita[at]riken.jp

Please replace [at] with @.

Taking theoretical and experimental approaches to reveal morphogenetic mechanisms of organ development

Developmental phenomena comprise a multiscalar system extending across a range of spatial scales, from molecular to cellular to histological. Such phenomena are also multiphysical, in that they involve the transmission and reception of positional information through diffusion and reactions of chemicals, and the generation of forces within tissues and concomitant geometrical deformation through the proliferation and migration of cells. The Laboratory for Developmental Morphogeometry takes theoretical and experimental approaches to the study of developmental phenomena comprising multiple scales and properties, and the quantitative measurement of dynamic and coordinated interactions between such phenomena.

Research Theme

  • Quantitative imaging and geometrical analysis of organ morphogenesis
  • Space-time recognition of cells in growing tissues
  • Mechanical modeling of organ morphogenesis
  • Measurement and modeling of spatial patterning processes through collective cell movement

Selected Publications

Ohtsuka D, Kida N, Lee SW, et al.
Cell disorientation by loss of SHH-dependent mechanosensation causes cyclopia.
Science Advances 8(28), eabn2330 Fri Jul 15 00:00:00 JST 2022 doi: 10.1126/sciadv.abn2330

Kawahira N, Ohtsuka D, Kida N, et al.
Quantitative analysis of 3D tissue deformation reveals key cellular mechanism associated with initial heart looping.
Cell Reports 30, 3889-3903 Tue Dec 01 00:00:00 JST 2020 doi: https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30239-4

Yamada T, Hironaka KI, Habara O, et al.
A developmental checkpoint directs metabolic remodelling as a strategy against starvation in Drosophila.
Nature metabolism 2(10), 1096-1112 Thu Oct 01 00:00:00 JST 2020 doi: 10.1038/s42255-020-00293-4

Suzuki T, Morishita Y.
A quantitative approach to understanding vertebrate limb morphogenesis at the macroscopic tissue level.
Current Opinion in Genetics and Development 45, 108-114 Fri Dec 01 00:00:00 JST 2017 doi: 10.1016/j.gde.2017.04.005

Lee SW, Morishita Y.
Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis.
Plos Computational Biology 13(7), e1005651 Wed Nov 01 00:00:00 JST 2017 doi: 10.1371/journal.pcbi.1005651

Morishita Y, Hironaka K, Lee SW, et al.
Reconstructing 3D deformation dynamics for curved epithelial sheet morphogenesis from positional data of sparsely-labeled cells.
Nature Communications 8, 15 Sun Oct 01 00:00:00 JST 2017 doi: 10.1038/s41467-017-00023-7

Hironaka K, Morishita Y.
Adaptive significance of critical weight for metamorphosis in holometabolous insects.
Journal of Theoretical Biology 417, 68-83 Fri Sep 01 00:00:00 JST 2017 doi: 10.1016/j.jtbi.2017.01.014

Morishita Y, Kuroiwa A, Suzuki T.
Quantitative analysis of tissue deformation dynamics reveals three characteristic growth modes and globally aligned anisotropic tissue deformation during chick limb development.
Development 142(9), 1672-1683 Tue Dec 01 00:00:00 JST 2015 doi: 10.1242/dev.109728

Morishita Y, Suzuki T.
Bayesian inference of whole-organ deformation dynamics from limited space-time point data.
Journal of Theoretical Biology 357, 74-85 Mon Dec 01 00:00:00 JST 2014 doi: 10.1016/j.jtbi.2014.04.027

Hironaka K, Morishita Y.
Encoding and decoding of positional information in morphogen-dependent patterning.
Current Opinion in Genetics and Development 22(6), 553-561 Sat Dec 01 00:00:00 JST 2012 doi: 10.1016/j.gde.2012.10.002

Morishita Y, Iwasa Y.
Coding Design of Positional Information for Robust Morphogenesis.
Biophysical Journal 101(10), 2324-2335 Thu Dec 01 00:00:00 JST 2011 doi: 10.1016/j.bpj.2011.09.048

Morishita Y, Iwasa Y.
Accuracy of positional information provided by multiple morphogen gradients with correlated noise.
Physical Review E 79(6), 061905 Tue Dec 01 00:00:00 JST 2009 doi: 10.1103/PhysRevE.79.061905

Morishita Y, Iwasa Y.
Optimal placement of multiple morphogen sources.
Physical Review E 77(4), 041909 Mon Dec 01 00:00:00 JST 2008 doi: 10.1103/PhysRevE.77.041909

PAGE
TOP