Team Leader
Yosky Kataoka
M.D., Ph.D.
Laboratory for Cellular Function Imaging
[Closed Mar. 2023]
Many diseases including neurological disorders and malignancy were caused by dysfunction of cells and tissues in our body. The dysfunction is thought to be induced by chronic inflammation and functional deterioration of tissue repair in aging or fatigue.
We are investigating the dynamics and pathophysiological roles of stem/progenitor cells functioning in living tissues under aging or fatigue condition, by using multi-modal imaging technologies including PET, MRI, fluorescence/bioluminescence imaging, microendoscope imaging, electron microscope imaging. In particular, we are focusing on the functions of immunological regulation and tissue maintenance by stem/progenitor cells. Further, we aim to uncover the functional linkages among organs, tissues, and cells in aging, fatigue, malignancy and neurological disorders, by the combination of such imaging technologies and omics analyses. In addition, we are challenging to develop new medical technologies using light energy or plasma for analysis and manipulation of function of stem/progenitor cells, immune system, tissue repair, and regeneration.
Research Theme
- Multi-modal imaging and functional analysis of stem/progenitor cells in vivo
- Pathophysiological studies of aging and fatigue by imaging and omics analysis
- Development of new technologies for analysis and control of bio-functions in vivo
Selected Publications
Sugita S, Yamato M, Hatabu T, Kataoka Y.
Involvement of cancer-derived EMT cells in the accumulation of 18F-fluorodeoxyglucose in the hypoxic cancer microenvironment.
Scientific Reports
11, 9668 (2021)
doi: 10.1038/s41598-021-88414-1
Tamura Y, Takata K, Eguchi A, et al.
Age-related changes in NG2-expressing telocytes in rat stomach.
PLOS ONE
16(4), e0249729 (2021)
doi: 10.1371/journal.pone.0249729
Konishi H, Okamoto T, Hara Y, et al.
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.
EMBO Journal
39, e104464 (2020)
doi: 10.15252/embj.2020104464
Kitami T, Fukuda S, Kato T, et al.
Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population.
Scientific Reports
10, 19933 (2020)
doi: 10.1038/s41598-020-77105-y
Tamura Y, Takata K, Eguchi A, Kataoka Y.
In vivo monitoring of hair cycle stages via bioluminescence imaging of hair follicle NG2 cells.
Scientific Reports
8, 393 (2018)
doi: 10.1038/s41598-017-18763-3
Nakano M, Tamura Y, Yamato M, et al.
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.
Scientific Reports
7, 42041 (2017)
doi: 10.1038/srep42041
Yamano E, Sugimoto M, Hirayama A, et al.
Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.
Scientific Reports
6, 34990 (2016)
doi: 10.1038/srep34990
Tamura Y, Takahashi K, Takata K, et al.
Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F] FLT-PET Imaging.
Journal of Neuroscience
36(31), 8123-8131 (2016)
doi: 10.1523/JNEUROSCI.0220-16.2016
Iwawaki T, Akai R, Oikawa D, et al.
Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo.
Scientific Reports
5, 17205 (2015)
doi: 10.1038/srep17205
Kume S, Yamato M, Tamura Y, et al.
Potential biomarkers of fatigue identified by plasma metabolome analysis in rats.
PLOS ONE
10(3), e0120106 (2015)
doi: 10.1371/journal.pone.0120106
Members
Yasuhisa Tamura
Deputy Team Director
Masanori Yamato
Research Scientist
Asami Eguchi
Technical Staff I
Kumi Takata
Technical Staff I
Sally Danno
Technical Staff I
Mayako Okamoto
Assistant
Kunpei Kawakatsu
Junior Research Associate
Mitsuyo Maeda
Senior Visiting Scientist
Kazuo Funabiki
Senior Visiting Scientist
Toshiyuki Goto
Visiting Scientist
Nozomu Kubota
Visiting Scientist
Chie Ueta
Visiting Technician
Yuki Okinaka
Student Trainee
Tomoka Akita
Research Part-time Worker II
Yoshika Seta
Research Part-time Worker II
Shizuka Kozaki
Research Part-time Worker II