Team Leader
Takuhiro Ito Ph.D.

Matsuura-Suzuki E, Shimazu T, Takahashi M, et al.
METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance.
eLife 11, e72780 Wed Jun 08 00:00:00 JST 2022 doi: 10.7554/eLife.72780

Kashiwagi K, Shichino Y, Osaki T, et al.
eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Nature Communications 12, 7102 Tue Dec 07 00:00:00 JST 2021 doi: 10.1038/s41467-021-27337-x

Zyryanova AF, Kashiwagi K, Rato C, et al.
ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B.
Molecular Cell 81, 88-103 Wed Dec 01 00:00:00 JST 2021 doi: 10.1016/j.molcel.2020.10.031

Yokoyama T, Machida K, Iwasaki W, et al.
HCV IRES Captures an Actively Translating 80S Ribosome.
Molecular Cell 74, 1205-1214 Sun Dec 01 00:00:00 JST 2019 doi: 10.1016/j.molcel.2019.04.022

Kashiwagi K, Yokoyama T, Nishimoto M, et al.
Structural basis for eIF2B inhibition in integrated stress response.
Science 364, 495-499 Fri Nov 01 00:00:00 JST 2019 doi: 10.1126/science.aaw4104

Iwasaki S, Iwasaki W, Takahashi M, et al.
The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA.
Molecular Cell 73, 738-748 Tue Oct 01 00:00:00 JST 2019 doi: 10.1016/j.molcel.2018.11.026

Kashiwagi K, Takahashi M, Nishimoto M, et al.
Crystal structure of eukaryotic translation initiation factor 2B.
Nature 531, 122-125 Thu Dec 01 00:00:00 JST 2016 doi: 10.1038/nature16991

Ito T, Masuda I, Yoshida K, et al.
Structural Basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD.
Proceedings of the National Academy of Sciences of the United States of America 112, E4197-E4205 Tue Dec 01 00:00:00 JST 2015 doi: 10.1073/pnas.1422981112

Ito T, Yokoyama S.
Two enzymes bound to one transfer RNA assume alternative conformations for consecutive reactions.
Nature 467, 612-616 Wed Dec 01 00:00:00 JST 2010 doi: 10.1038/nature09411

Goto-Ito S, Ito T, Kuratani M, et al.
Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation.
Nature Structural & Molecular Biology 16, 1109-1115 Tue Dec 01 00:00:00 JST 2009 doi: 10.1038/nsmb.1653