Team Leader
Yi-Long Cui
Ph.D.
Laboratory for Biofunction Dynamics Imaging
[Closed Mar. 2023]
E-mail cuiyl[at]riken.jp
Please replace [at] with @.
Over millions of years of evolution, living organisms have developed an optimum internal environment, and functional molecules involved in complex hierarchical systems precisely interact with the surrounding microenvironment to ensure an optimum state is maintained. Deviations from the optimum state are known to suppress the functional performance and/or induce disease due to the disruption of the spatial-temporal dynamics of functional molecules in these complex systems. For the purpose of comprehensively exploring the molecular dynamics in complex systems, we are trying to establish an integrated research system combining positron emission tomography and classic research techniques, including electrophysiology, behavioral pharmacology, histology and genetic engineering approaches, and to thereby carry out comprehensive investigations covering the entire hierarchy of molecules, cells, organs and systems. We are particularly interested in unlocking the mysteries of the brain, especially regarding such factors as placebo analgesia and fatigue sensation.
Research Theme
- Development of a PET imaging based integrated research system to elucidate the molecular/cellular mechanisms of the psychiatric processes
- Establishment of PET imaging-based evaluation platform for pharmacokinetics
- Development of cancer-specific PET imaging methods and evaluation of novel diagnostic & therapeutic drug efficacy
Selected Publications
Hu D, Li D, Shigeta M, et al.
Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.
Biochemical and Biophysical Research Communications
535, 1-5 (2021)
doi: 10.1016/j.bbrc.2020.12.035
Zeng Y, Hu D, Yang W, et al.
A voxel-based analysis of neurobiological mechanisms in placebo analgesia in rats.
NeuroImage
178, 602-612 (2018)
doi: 10.1016/j.neuroimage.2018.06.009
Fujita S, Mizoguchi N, Aoki R, et al.
Cytoarchitecture-dependent decrease in propagation velocity of cortical spreading depression in the rat insular cortex revealed by optical imaging.
Cerebral Cortex
26(4), 1580-1589 (2016)
doi: 10.1093/cercor/bhu336
Kanzaki A, Okauchi T, Hu D, et al.
Extension of recovery time from fatigue by repeated rest with short-term sleep during continuous fatigue load: Development of chronic fatigue model.
Journal of Neuroscience Research
94(5), 424-429 (2016)
doi: 10.1002/jnr.23718
Cui YL, Toyoda H, Sako T, et al.
A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.
NeuroImage
108, 17-22 (2015)
doi: 10.1016/j.neuroimage.2014.12.047
Mukai H, Ozaki D, Cui Y, et al.
Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with F-18-incorporated oligodeoxynucleotides.
Journal of Controlled Release
180, 92-99 (2014)
doi: 10.1016/j.jconrel.2014.02.014
Sako T, Hasegawa K, Nishimura M, et al.
Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with 68Ga-DOTA-octreotide: a potential PET tracer for beta cell mass measurement.
Biochemical and biophysical research communications
442(1-2), 79-84 (2013)
doi: 10.1016/j.bbrc.2013.11.001
Shingaki T, Takashima T, Ijuin R, et al.
Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion Using Newly Developed Positron Emission Tomography Tracer [C-11]Dehydropravastatin in Rats.
Journal of Pharmacology and Experimental Therapeutics
347(1), 193-202 (2013)
doi: 10.1124/jpet.113.206425
Takashima T, Nagata H, Nakae T, et al.
Positron emission tomography studies using (15R)-16-m-[11 C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.
Journal of Pharmacology and Experimental Therapeutics
335(2), 314-323 (2010)
doi: 10.1124/jpet.110.170092
Akazawa KH, Cui YL, Tanaka M, et al.
Mapping of regional brain activation in response to fatigue-load and recovery in rats with c-Fos immunohistochemistry.
Neuroscience Research
66(4), 372-379 (2010)
doi: 10.1016/j.neures.2009.12.009
Cui YL, Takashima T, Takashima-Hirano M, et al.
11 C-PK11195 PET for the in vivo evaluation of neuroinflammation in the rat brain after cortical spreading depression.
Journal of Nuclear Medicine
50(11), 1904-1911 (2009)
doi: 10.2967/jnumed.109.066498
Cui YL, Takamatsu H, Kakiuchi T, et al.
Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: a positron emission tomography study.
Stroke
37(11), 2830-2836 (2006)
doi: 10.1161/01.STR.0000245088.60282.22
Members
Di Hu
Research Scientist
Hiroyuki Neyama
Research Scientist
YuPing Wu
Technical Staff I
Michiko Inoue
Technical Staff I
Mika Shigeta
Technical Staff I
Yuta Ochi
Technical Staff I
Naoko Ueda
Assistant